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KMID : 0385219990090020007
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Korean Journal of Gerontology
1999 Volume.9 No. 2 p.7 ~ p.14
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The Effect of Exercise, Vitamin B6, B12 and Folic Acid on Plasma homocysteine Concentration (tHcy) in Elderly People
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Hong Seung-Youn
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Abstract
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Background: Despite progressive decline in age-adjusted mortality rate from coronary heart disease(CHD), coronary heart disease is still the major killing disease in the Unite States. Although several factors have contributed to the rise in CHD, recently elevated blood homocysteine concentration(tHcy) is newly recognized as an independent risk factor for CHD. It was also reported that plasma tHcy level increased Progressively with age. The meta-analysis referred that the vitamin B6 , B12, and folate appear to be effective single agent for reducing a tHcy level and several studies showed prolonged exercise affects the metabolism of vitamin B6 and B12. However there is no study which links these two results together.
Purpose: The purpose of this study is to 1) examine if exercise affects plasma homocysteine level (tHcy)perse, 2) see if exercise increases the plasma level of vitamin B6, B12 and folate so that exercise gives positive impact on tHcy, and 3) finally suggest a study investigating the effect of diet-exercise intervention on homocysteine levels in the elderly. The results should be helpful for elderly people as showing the benefits of exercise and diet for reducing CHD risk.
Methods: This study was conducted through literature reviews about plasma concentration of a homocysteine level which is a newly recognized risk factor of CHD and vitamin B metabolism.
Conclusion: Physical activity can be reasonably expected to enhance vitamin B group metabolism and reduce plasma homocysteine level perse. Therefore if subsequent studies in this area prove the effect of physical activity on lowering tHcy, it could prevent tens of thousands of cases of cardiovascular disease each year at very low cost and with few (if any) adverse effects. Thus further research is required in the area.
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KEYWORD
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Homocysteine, Coronary, heart disease, Exercise vitamin, B6, B12, Folic acid
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